The trial has some limitations. Patients had been excluded from the trial if indeed they had nonsevere ANCA-associated vasculitides, were ANCA-detrimental, had alveolar hemorrhage serious enough to require ventilatory support, or acquired advanced renal dysfunction (serum creatinine level, >4.3,8 Thus, the comparative efficacy of both treatment regimens for such sufferers remains uncertain. To conclude, our results indicate that for the treating severe ANCA-associated vasculitis, an individual span of rituximab, at a dose of 375 mg per square meter once weekly for 4 weeks, combined with glucocorticoids is certainly not inferior to 18 months of the traditional regimen of glucocorticoids and cyclophosphamide accompanied by maintenance therapy with azathioprine..These are used for diseases of the immune and haematopoietic systems. In the Biotherapeutic segment, Biotest researches in to the clinical development of monoclonal antibodies, including in the indications of arthritis rheumatoid and cancers of plasma cells. Biotest has more than 1.600 employees worldwide. The preference shares of Biotest AG are shown in the SDAX on the Frankfurt stock exchange. About Abbott Abbott is a worldwide, broad-based healthcare company devoted to the discovery, development, marketing and manufacture of pharmaceuticals and medical products, including nutritionals, devices and diagnostics.