The findings were scheduled for presentation Saturday at the ECNP’s annual meeting in Amsterdam. One expert in the United States concurred with the findings. ‘It is definitely known that those sufferers with melancholy who also experience anxiety and/or agitation are more likely to attempt or complete suicide,’ said Dr. Donald Malone, chair of psychiatry and psychology at the Cleveland Clinic. ‘These symptoms may also be a clue that the underlying analysis is bipolar depression ,’ he added. In the scholarly study, Popovic’s team looked at a lot more than 2,800 people with depression, including nearly 630 who had attempted suicide.Hirschfield, M.R.C.P., Ph.D., Xiangdong Liu, Ph.D., Chun Xu, M.D., Ph.D., Yue Lu, M.Sc., Gang Xie, M.D., Ph.D., Yan Lu, M.D., Xiangjun Gu, Ph.D., Erin J. Walker, Ph.D., Kaiyan Jing, M.S., Brian D. Juran, B.S., Andrew L. Mason, M.D., Robert P. Myers, M.D., Kevork M. Peltekian, M.D., Cameron N. Ghent, M.D., Catalina Coltescu, Elizabeth J. Atkinson, M.S., E. Jenny Heathcote, M.D., Konstantinos N. Lazaridis, M.D., Christopher I. Amos, Ph.D., and Katherine A. Siminovitch, M.D.: Principal Biliary Cirrhosis Associated with HLA, IL12A, and IL12RB2 Variants Primary biliary cirrhosis is the most common autoimmune liver disease, affecting up to 1 1 in 1000 women over 40 years.1 Treatment because of this chronic cholestatic condition remains empirical.2 The granulomatous destruction of interlobular bile ducts that characterizes principal biliary cirrhosis is almost always connected with antimitochondrial antibodies specific for the E2 subunit of the pyruvate dehydrogenase complex.4-6 A genetic predisposition for principal biliary cirrhosis has been revealed by analysis of both aggregation data from families and concordance data from twins.