Adiposity associated with cognitive decline in elderly By Sarah Guy.

Furthermore, in participants aged 70 years and older, Park et al noticed no association between poor cognitive overall performance and BMI, visceral or subcutaneous adipose tissue, indicating that the effects are attenuated by age group. ‘Aging is characterized by lean body mass loss and adipose tissue boost without excess weight gain,’ clarify the experts. ‘Our findings need to be confirmed by prospective large population study,’ they conclude. Licensed from medwireNews with permission from Springer Healthcare Ltd.Ricolinostat's great synergy with IMiDs and proteasome inhibitors is exemplified by the early signs of clinical activity inside our current clinical research with lenalidomide and bortezomib, and we believe this profile is enhanced by these preclinical research with the next-generation compounds, pomalidomide, ixazomib and carfilzomib, commented Catherine A. Wheeler, MD, Vice President, Scientific Advancement of Acetylon. These data underscore our strategy to expand the scientific exploration of ricolinostat's potential in additional indications and combinations with the support of our collaboration with Celgene.