A lot of people have acne on the face. However, additionally it is quite typical to have pimples on the arms. Acne not merely mar the physical beauty of the person but also result in mental tension because of worries of developing permanent scars. About 50 percent of the acne sufferers have lesions on the facial skin and arms. As regarding face, the arms likewise have hair roots that are well connected to the essential oil secreting glands. These glands usually get blocked because of the dead oil and skin resulting in the occurrence of acne. People who dress up in tight fit clothes and individuals who profusely sweat are in a higher threat of developing acne on the hands.Adverse Events The safety profile of crizotinib in this study was similar to that reported previously.22,24 Treatment-related adverse events which were observed in at least 10 percent of the patients are listed in Desk 2Desk 2Adverse Events.; the most typical events were visual impairment , diarrhea , nausea , peripheral edema , constipation , vomiting , an elevated aspartate aminotransferase level , fatigue , dysgeusia , and dizziness . Of the 388 treatment-related adverse events that were reported, 365 were grade one or two 2. Of the 42 visual-impairment events which were reported, all were grade 1; they were referred to as brief picture persistence triggered by dark-to-light adaptation often, as reported previously.22 One individual discontinued crizotinib because of treatment-related nausea.