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Critics say the medication is normally over-prescribed. In the scholarly study, 132 subjects aged between 12 and 19 were examined for depression before and three or four months after taking the drug. In the group who took the drug, the %age discovered to be depressed dropped to 8 % from 14 %. The depression price in the control group stayed a comparable. Another recent study released this month in the American Journal of Psychiatry, showed that human brain scans on adults taking the drug showed a reduction in brain metabolism within an area of the frontal cortex that is connected with mediating depressive symptoms.Basic safety of Ribavirin Therapy Before ribavirin therapy, the median hemoglobin level was 13.4 g per deciliter , and 15 patients were receiving recombinant erythropoietin. During therapy, hemoglobin levels decreased significantly, to a median of 11.6 g per deciliter by the end of therapy . Overall, 32 sufferers received recombinant erythropoietin on a transient or regular basis during ribavirin therapy, and 24 sufferers received recombinant erythropoietin by the end of therapy. Seven individuals required a bloodstream transfusion; 2 of the patients were getting chemotherapy for cancers concomitantly, and 1 of the 2 2 patients acquired a sustained virologic response.